Meet The Team How-Tos Our Supporters How to Participate in Precision Panc Membership Meeting Minutes Remit of Steering Committee Patient Stories Documents Working with the NHS Patient Public Engagement Meetings Governance News Clinicians Area Clinical Trials What is precision medicine? Information and Support What is Pancreatic Cancer? Current Research Our Researchers Privacy Policy Patients and Carers Contact Us About us Home
Patient 600 recruited Precision-Panc Enters 500th patient to platform Professor Andrew Biankin – it’s about time Pancreatic Cancer is debated in the Scottish Parliament Please watch this very moving video from NIHR West of England Exciting week for the Precision-Panc project Glasgow to host Pancreatic Symposium – Friday 21st May 2021 Survey on the impact of COVID-19 pandemic on pancreatic cancer research Precision-Panc in the Press Precision-Panc / PRIMUS 002 Opens a new site Precision-Panc Re-opens to Recruitment Information on COVID-19 and Pancreatic Cancer from PCUK Precision-Panc and PRIMUS studies suspended to recruitment Precision-Panc Recruits Patient 300 Paul Taylor tells us about his Precision-Panc experience Precision-Panc help raise funds for Pancreatic Cancer Scotland Precision-Panc Recruits Patient 250 Marking World Pancreatic Cancer Day Precision-Panc working with myTomorrows Precision-Panc Roundtable Final Report New Glasgow Cancer Assays by GPOL and Agilent Technologies Precision-Panc opens site 25! Precision-Panc Summer Newsletter Precision-Panc Recruits Patient 200! Precision-Panc Brochure Royal Bournemouth Hospital Opens Finding the right treatment for the patient CRUK animate the Precision-Panc platform CRUK / Precision-Panc Video Professor Biankin receives the Order of Australia in Queen’s Birthday Honours Precision-Panc opens its 20th Site Precision Panc Spring Newsletter Precision-Panc Opens Site 19 Recent Media Pieces Regarding 100 Patient Milestone Site 17 opens for Precision-Panc PRIMUS 002 opens Informing the Future of Genomic Medicine in Scotland Report is Published St James’s University Hospital Opens Precision-Panc Opens its 15th site Glasgow Experts Lead UK Pancreatic Cancer Research 11th site opens to PRECISION-Panc Scotsman Conferences Blogspot November is Pancreatic Cancer Awareness Month First Precision-Panc Trial Opens In Glasgow Cancer Research UK Investment Landscape of pancreatic neuroendocrine cancer Whole Genome Sequencing from EUS biopsies Upcoming Pancreas 2016 Conference Scottish Genome Partnership Announced Identification of four Pancreatic Cancer subtypes offers new treatment insight into the disease First Minister announces £4m ‘Precision Medicine Ecosystem’
Home | Patients and Carers | Clinical Trials

What is a clinical trial?

A medical research study that involves people, whether healthy or not, is called a clinical trial.  Each stage of the trial is known as a “phase”. There are four phases of clinical trial that take place one after the other, but only if the previous phase is successful. 

Not all treatments will pass all the phases required to become a standard option and not all trials will prove beneficial for the patient involved.

Clinical trials are used to:

  • understand the risks and causes of disease
  • screen people known to be at risk of developing diseases like cancer
  • test new treatments or combinations of existing treatments
  • investigate options to minimise or control the symptoms of disease and/or the side effects of treatments

For a list of current pancreatic caner trials recruiting in the UK please click the link below to the Pancreatic Cancer UK’s Trial Finder

The myTomorrows platform offers information and facilitates access to Clinical Trials and Expanded Access Programs available worldwide. They are dedicated to helping patients who have exhausted their regular treatment options, a link to their website is below:

Phase I

Phase I trials check the safety of a new therapy and take place after laboratory testing has shown that a new treatment, or changing the way existing treatments are given, may be more effective when treating cancer.
People in these trials are normally healthy but will often include patients that have advanced cancer and have exhausted all conventional treatment options available to them. Participants in these trials may or may not benefit from the trial.
Phase I trials:
• include a small number of people (usually between 20-100)
• are usually the first time a treatment has been tested on humans
• by starting the trial using small doses, it aims to find out more about the most effective dose to use
• identify any side effects of treatments
• may last for a significant length of time

Phase II

Phase II trials take place after a successful Phase I trial and are carried out in order to understand how well the treatment works.
Sometimes Phase II trials are split into two trials known as Phase IIA and Phase IIB.
• Phase IIA is designed to work out how much medicine should be given
• Phase IIB is designed to understand how well the drug works at the prescribed dose(s)

In general all Phase II trials are very similar to Phase I but are:
• carried out on a larger number of people (typically between 100 and 300 people) who may, or may not, have the same type of cancer
• aim to understand if a treatment works as well as (or better than) standard treatments
• aim to understand if a treatment works better in specific cancer types
• investigate the side effects and dosage to use

Phase III and IV

Phase III trials are carried out in order to confirm that the findings of the previous phases are still true in an even larger patient population.
Generally they:
• Include much larger numbers of patients (usually >1000)
• Compare treatments to existing treatments or a placebo to test whether the new treatment works better
• Continue to check for side effects

Phase IV trials test long-term safety in a diverse patient population. These trials take place once a treatment has passed all the previous phases and the treatment is available on prescription. Some people that have not been tested in Phases 1- 3 may show adverse reactions during a phase IV trial. Not all treatments will go into a Phase IV trial.

Benefits of clinical trials

Clinical trials are used to understand if a particular treatment is better than another but may not benefit the participant personally.
This means that your treatment and progress could be monitored more closely than when you undertake standard therapies. Once the trial has finished, it might be possible for your doctor to offer you more appropriate and effective treatment to you.
Clinical trials are essential for the development of new and better treatments. They may help you get more information for your future treatments. You will be helping the NHS learn what the best possible standard of care is and how that care should be given in future.

Disadvantages of clinical trials

There can be some disadvantages to taking part in a clinical trial. This is because no one can be 100% sure what the outcome will be for you.
This could be because the treatment is not as effective as hoped when compared to standard treatment. You may develop unexpected side effects. You may have to have more tests or visits to the clinic than you would if you were receiving the standard treatment for your disease.

Questions to ask your doctor about clinical trials

When deciding whether to participate in a clinical trial or not, there are a number of questions you may wish to ask so that you understand what impact the trial may or may not have on you. Some questions that you may wish to ask your doctor include:
• What is the purpose of the trial and how will it help people like me?
• Who is paying for the trial?
• How long will the trial last and how long will I be taking part?
• When will the results of the trial be known?
• If I decide not to participate, what other treatment(s) will get?
• What will happen if I decide to leave the trial before it finishes?
• Will the results of the trial be published openly?
• There are some much more practical questions to think about too, such as:
• What extra tests or appointments are needed in addition to my standard care?
• Will I need to take time off work?
• How much time will I need to give to the trial?
• If the trial includes new medicines, how will it be given to me?
• Will I have to collect the medicine from the hospital, from my doctor or will it be sent through the post to me?
• Will there be any help to cover the costs of my travel to participate in the trial?
• Do you know if the treatment will have any side effects? If so, what are they?
• Do you know if the treatments may have an affect on me physically or emotionally?
• Who can I contact if I have questions or a problem?
• Will they be available 24 hours a day?
• How do I find out the results of the trial?

© 2024 Precision Panc
Web design by Creatomatic
This site uses cookies.
Read our privacy policy

This site uses cookies for marketing, personalisation, and analysis purposes. You can opt out of this at any time or view our full privacy policy for more information.